cv
Basics
| Name | Yanzi Sun |
| Label | Bioinformatician/Biostatistician |
| yanzisun@g.ucla.edu | |
| Url | https://www.linkedin.com/in/yanzi-sun/ |
| Summary | A data scientist-in-training with a background in bioinformatics and machine learning, dedicated to advancing biomedical research through computational innovation. |
Work
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2024.10 - Present Bioinformatician
Roel Ophoff Lab, UCLA Psychiatry and Human Genetics
Project: Meta-analysis of epigenetic aging in bipolar disorder.
- Performed large-scale bioinformatics analysis of genome-wide DNA methylation profiles from bipolar disorder cohorts, leveraging advanced DNA methylation clocks to dissect associations between epigenetic aging and clinical phenotypes, such as chronological age, sex, illness duration.
- Utilized high-performance computing clusters (hoffman2) to execute parallelized preprocessing workflows, including quality control, normalization, and feature extraction of methylation data.
- Developed and optimized statistical models in R using packages such as dnaMethyAge, minfi, limma, integrating machine learning techniques including regularized regression (Lasso, Ridge), random forests, and gradient boosting.
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2023.06 - 2024.06 Research Assistant
Chao Peng Lab, UCLA Neurology
Project: Uncover XX vs. XY differences in AD and PD pathology using Four Core Genotypes (FCG) mouse model.
- Design and conduct experiments on tau and mouse α-Syn preformed fibrils (PFFs) preparation.
- Stereotactic injection of Amyloid-β and α-syn PFF in 5XFAD mice; mouse husbandry and colony management; in vivo miniscope calcium imaging; spatial memory behavioral testing.
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2022.06 - 2023.04 Research Assistant
Soojin Yi Lab, UCSB EEMB
Project: Connecting Epigenome to Health in Marine Organisms.
- Conducted DNA methylation studies on marine organisms to develop DNA methylation clocks.
- Processed DNA extracted from mussel and starfish tissues for Reduced Representation Bisulfite Sequencing (RRBS), optimizing bioinformatics pipelines.
- Developed Python-based tools for automated shell ring counting and standardized workflows for 3D shell scanning and DNA extraction.
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2022.06 - 2023.04 Research Assistant
Susan Mazer Lab, UCSB EEMB
Project: Computational Analysis of Style Length Impact on Pollination Efficacy and Reproductive Fitness in Nemophila menziesii.
- Investigated the relationship between style length and pollination efficacy, testing its correlation with lifetime fecundity using linear regression, ANOVA, and mixed-effects models in R.
- Digitized pollen, seed count, and flower size data; implemented interactive data visualization dashboards in R Shiny.
- Developed automated data preprocessing pipelines in R to identify phenotypic patterns from microscopy observations.
Education
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2024.09 - 2026.06 Los Angeles, CA
Master of Science
University of California, Los Angeles
Data Science
- Introduction to Data Science
- Principles of Biostatistics
- Machine Learning
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2019.09 - 2022.09 Goleta, CA